PEBP1_HUMAN
Source: hRBCD ; ID: IPI00219446PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: PEBP1 , PBP, PEBP
Protein names and data: PEBP1_HUMAN , Phosphatidylethanolamine-binding protein 1; PEBP-1 , HCNPpp; Neuropolypeptide h3; Prostatic-binding protein; Raf kinase inhibitor protein; RKIP; Hippocampal cholinergic neurostimulating peptide; HCNP Lenght: 187 a.a.
Mass: 21057 Da
fasta formatted sequence
Function: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).
Cellular location: Cytoplasm (By similarity).
Genetic variants
Database cross-references
UniProt: P30086Ensembl: ENST00000261313
MIM: 604591
neXtProt: NX_P30086
Antibodypedia: P30086 (may not find the protein thus also not any antibody)
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