Source: BSc_CH
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: EPX , EPER, EPO, EPP
Protein names and data: PERE_HUMAN , Eosinophil peroxidase; EPO;; Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain; Flags: Precursor Lenght: 715 a.a.
Mass: 81040 Da
fasta formatted sequence

Function: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
Catalytic activity: 2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O.
Cellular location: Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.

Genetic variants

Allelic variant in EPX is associated with Japanese cedar pollinosis which is a type I allergic disease with ocular and nasal symptoms that develop paroxysmally on contact with Japanese cedar pollen. These symptoms, which occur seasonally each year, are typical features of allergic rhinitis, such as sneezing, excessive nasal secretion, nasal congestion, and conjunctival itching.

Database cross-references

UniProt: P11678
Ensembl: ENST00000225371
MIM: 131399
MIM: 261500
neXtProt: NX_P11678
Antibodypedia: P11678 (may not find the protein thus also not any antibody)
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