PHAR4_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PHACTR4 , PRO2963
Protein names and data: PHAR4_HUMAN , Phosphatase and actin regulator 4 Lenght: 702 a.a.
Mass: 78211 Da
fasta formatted sequence
Function: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).
Cellular location: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity).

Database cross-references

UniProt: Q8IZ21
Ensembl: ENST00000373836
Ensembl: ENST00000373839
MIM: 608726
neXtProt: NX_Q8IZ21
Antibodypedia: Q8IZ21 (may not find the protein thus also not any antibody)
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