PHB2_HUMAN

Source: BSc_CH
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: PHB2 , BAP, REA
Protein names and data: PHB2_HUMAN , Prohibitin-2 , B-cell receptor-associated protein BAP37; D-prohibitin; Repressor of estrogen receptor activity Lenght: 299 a.a.
Mass: 33296 Da
fasta formatted sequence
Function: Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.
Cellular location: Mitochondrion inner membrane (By similarity). Cytoplasm (By similarity). Nucleus (By similarity). Note=Also cytoplasmic and nuclear (By similarity).

Database cross-references

UniProt: Q99623
Ensembl: ENST00000440277
Ensembl: ENST00000535923
Ensembl: ENST00000607236
Ensembl: ENST00000607454
MIM: 610704
neXtProt: NX_Q99623
Antibodypedia: Q99623 (may not find the protein thus also not any antibody)
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