PHS2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PCBD2 , DCOH2, DCOHM
Protein names and data: PHS2_HUMAN , Pterin-4-alpha-carbinolamine dehydratase 2; PHS 2; 4.2.1.96 , 4-alpha-hydroxy-tetrahydropterin dehydratase 2; DcoH-like protein DCoHm; Dimerization cofactor of hepatocyte nuclear factor 1 from muscle; HNF-1-alpha dimerization cofactor Lenght: 130 a.a.
Mass: 14365 Da
fasta formatted sequence
Function: Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1- alpha and enhances its transcriptional activity.
Catalytic activity: (6R)-6-(L-erythro-1,2-dihydroxypropyl)- 5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2- dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O.

Database cross-references

UniProt: Q9H0N5
Ensembl: ENST00000254908
Ensembl: ENST00000512783
MIM: 609836
neXtProt: NX_Q9H0N5
Antibodypedia: Q9H0N5 (may not find the protein thus also not any antibody)
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