Source: hRBCD ; ID: IPI00472438
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: PICALM , CALM
Protein names and data: PICAL_HUMAN , Phosphatidylinositol-binding clathrin assembly protein , Clathrin assembly lymphoid myeloid leukemia protein Lenght: 652 a.a.
Mass: 70755 Da
fasta formatted sequence

Function: Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.
Cellular location: Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Colocalized with clathrin in the Golgi area. Interaction with FAM64A may target PICALM to the nucleus in some cells.
Tissue specificity: Expressed in all tissues examined.

Genetic variants

Database cross-references

UniProt: Q13492
Ensembl: ENST00000356360
Ensembl: ENST00000393346
Ensembl: ENST00000526033
Ensembl: ENST00000528398
Ensembl: ENST00000532317
MIM: 603025
neXtProt: NX_Q13492
Antibodypedia: Q13492 (may not find the protein thus also not any antibody)
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