Source: hRBCD ; ID: IPI00006093
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: PIEZO1 , FAM38A, KIAA0233
Protein names and data: PIEZ1_HUMAN , Piezo-type mechanosensitive ion channel component 1 , Membrane protein induced by beta-amyloid treatment; Mib; Protein FAM38A Lenght: 2521 a.a.
Mass: 286790 Da
fasta formatted sequence

Function: Pore-forming subunit of a mechanosensitive non-specific cation channel, that conducts both sodium and potassium ions. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling.
Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane; Multi-pass membrane protein. Note=In erythrocytes, located in the plasma membrane.
Tissue specificity: Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. Expressed in erythrocytes (at protein level).

Genetic variants

Database cross-references

UniProt: Q92508
Ensembl: ENST00000301015
MIM: 194380
MIM: 611184
neXtProt: NX_Q92508
Antibodypedia: Q92508 (may not find the protein thus also not any antibody)
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