PIMT_HUMAN

Source: hRBCD ; ID: IPI00024989
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: PCMT1
Protein names and data: PIMT_HUMAN , Protein-L-isoaspartate(D-aspartate) O-methyltransferase; PIMT; 2.1.1.77 , L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase Lenght: 227 a.a.
Mass: 24636 Da
fasta formatted sequence
Function: Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl- terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).
Catalytic activity: S-adenosyl-L-methionine + protein L- isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.
Cellular location: Cytoplasm.

Genetic variants

The allele frequencies for the polymorphism at codon 120 differ between ethnic groups; in the Caucasian population Ile- 120 is present at a frequency of 0.45, while it is found at a frequency of 0.88 and 0.81 in the Asian and the African populations respectively. Val-120 is found at a frequency of 0.55 in the Caucasians, 0.12 and 0.19 in the Asian and African populations respectively. The Ile-120 variant has higher specific activity and thermostability than the Val-120 variant. The Val-120 variant has a higher affinity for protein substrates.

Database cross-references

UniProt: P22061
Ensembl: ENST00000367380
MIM: 176851
neXtProt: NX_P22061
Antibodypedia: P22061 (may not find the protein thus also not any antibody)
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