PIN1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PIN1
Protein names and data: PIN1_HUMAN , Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; 5.2.1.8 , Peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; Rotamase Pin1 Lenght: 163 a.a.
Mass: 18243 Da
fasta formatted sequence
Function: Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner.
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
Cellular location: Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with NEK6 in the nucleus. Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization.
Tissue specificity: The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells.

Database cross-references

UniProt: Q13526
Ensembl: ENST00000247970
Ensembl: ENST00000588695
MIM: 601052
neXtProt: NX_Q13526
Antibodypedia: Q13526 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.