PIN4_HUMAN

Source: hRBCD ; ID: IPI00006658
PM19886704
PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: PIN4
Protein names and data: PIN4_HUMAN , Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; 5.2.1.8 , Parvulin-14; Par14; hPar14; Parvulin-17; Par17; hPar17; Peptidyl-prolyl cis-trans isomerase Pin4; PPIase Pin4; Peptidyl-prolyl cis/trans isomerase EPVH; hEPVH; Rotamase Pin4 Lenght: 131 a.a.
Mass: 13810 Da
fasta formatted sequence
Function: Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. Isoform 2 binds to double-stranded DNA.
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
Cellular location: Isoform 1: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1. Isoform 2: Mitochondrion. Mitochondrion matrix. Note=Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N- terminal domain that functions as non-cleavable mitochondrial targeting peptide.
Tissue specificity: Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed.

Database cross-references

UniProt: Q9Y237
Ensembl: ENST00000373669
Ensembl: ENST00000423432
MIM: 300252
neXtProt: NX_Q9Y237
Antibodypedia: Q9Y237 (may not find the protein thus also not any antibody)
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