Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: PLEKHF2 , ZFYVE18
Protein names and data: PKHF2_HUMAN , Pleckstrin homology domain-containing family F member 2; PH domain-containing family F member 2 , Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains; EAPF; PH and FYVE domain-containing protein 2; Phafin-2; Phafin2; Zinc finger FYVE domain-containing protein 18 Lenght: 249 a.a.
Mass: 27798 Da
fasta formatted sequence

Function: May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467).
Cellular location: Early endosome membrane; Peripheral membrane protein. Endoplasmic reticulum. Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots. May translocate to the endoplasmic reticulum in the early phase of apoptosis (PubMed:18288467).
Tissue specificity: Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells.

Database cross-references

UniProt: Q9H8W4
Ensembl: ENST00000315367
Ensembl: ENST00000519516
MIM: 615208
neXtProt: NX_Q9H8W4
Antibodypedia: Q9H8W4 (may not find the protein thus also not any antibody)
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