Source: PM23856902
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: AGPAT3 , LPAAT3 , UNQ759/PRO1490
Protein names and data: PLCC_HUMAN , 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; , 1-acylglycerol-3-phosphate O-acyltransferase 3; 1-AGP acyltransferase 3; 1-AGPAT 3; Lysophosphatidic acid acyltransferase gamma; LPAAT-gamma Lenght: 376 a.a.
Mass: 43381 Da
fasta formatted sequence

Function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA.
Catalytic activity: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.
Tissue specificity: Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver.

Database cross-references

UniProt: Q9NRZ7
Ensembl: ENST00000291572
Ensembl: ENST00000327505
Ensembl: ENST00000398058
Ensembl: ENST00000398061
Ensembl: ENST00000398063
Ensembl: ENST00000546158
MIM: 614794
neXtProt: NX_Q9NRZ7
Antibodypedia: Q9NRZ7 (may not find the protein thus also not any antibody)
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