PLMN_HUMAN
Source:
PM23856902
Marked as 'Non-membrane protein'
Confidence:
low (only semi-automatic identification from reviews)
Search PubMed for
(RBC AND this entry)
Gene names:
PLG
Protein names and data:
PLMN_HUMAN
, Plasminogen; 3.4.21.7; Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B; Flags: Precursor
Lenght: 810 a.a.
Mass: 90569 Da
fasta formatted sequence
Function:
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
Catalytic activity:
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.
Disease:
( OMIM:
173350
217090
)
Plasminogen deficiency (PLGD) [MIM:217090]: A disorder characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa. Note=The disease is caused by mutations affecting the gene represented in this entry.
Cellular location:
Secreted. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
Tissue specificity:
Present in plasma and many other extracellular fluids. It is synthesized in the liver.
Genetic variants
38 - 38
K -> E (in PLGD; common mutation; dbSNP:rs73015965). VAR_018657
73015965
46 - 46
I -> R (in dbSNP:rs1049573). VAR_011779
1049573
57 - 57
E -> K (in dbSNP:rs4252070). VAR_016287
4252070
133 - 133
H -> Q (in dbSNP:rs4252186). VAR_016288
4252186
134 - 134
R -> K (in dbSNP:rs2817). VAR_033653
2817
147 - 147
L -> P (in PLGD). VAR_018658
235 - 235
R -> H (in PLGD; severe type 1 deficiency). VAR_018659
261 - 261
R -> H (in dbSNP:rs4252187). VAR_016289
4252187
374 - 374
V -> F (in PLGD; Nagoya-1; dbSNP:rs121918028). VAR_006627
121918028
408 - 408
R -> W (in dbSNP:rs4252119). VAR_016290
4252119
453 - 453
K -> I (in dbSNP:rs1804181). VAR_011780
1804181
472 - 472
D -> N (in dbSNP:rs4252125). VAR_016291
4252125
494 - 494
A -> V (in dbSNP:rs4252128). VAR_016292
4252128
523 - 523
R -> W (in dbSNP:rs4252129). VAR_016293
4252129
532 - 532
R -> H (in PLGD). VAR_018660
591 - 591
S -> P (in PLGD; may be associated with susceptibility to thrombosis). VAR_006628
620 - 620
A -> T (in PLGD; type 2 plasminogen deficiency; decreased activity; Nagoya-2/ Tochigi/Kagoshima; may be associated with susceptibility to thrombosis; dbSNP:rs121918027). VAR_006629
121918027
676 - 676
V -> D (in dbSNP:rs17857492). VAR_031213
17857492
751 - 751
G -> R (in PLGD; Kanagawa-1; 50% activity). VAR_006630
Database cross-references
UniProt:
P00747
Ensembl:
ENST00000308192
MIM:
173350
MIM:
217090
neXtProt:
NX_P00747
Antibodypedia:
P00747
(may not find the protein thus also not any antibody)
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