Source: hRBCD ; ID: IPI00217600
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: PNPLA6 , NTE
Protein names and data: PLPL6_HUMAN , Neuropathy target esterase; , Patatin-like phospholipase domain-containing protein 6 Lenght: 1366 a.a.
Mass: 149995 Da
fasta formatted sequence

Function: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
Catalytic activity: 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Cellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino- terminal transmembrane segment.
Tissue specificity: Expressed in brain, placenta, kidney, neuron and skeletal muscle.

Genetic variants

Database cross-references

UniProt: Q8IY17
Ensembl: ENST00000221249
Ensembl: ENST00000414982
Ensembl: ENST00000450331
Ensembl: ENST00000545201
Ensembl: ENST00000600737
MIM: 603197
MIM: 612020
neXtProt: NX_Q8IY17
Antibodypedia: Q8IY17 (may not find the protein thus also not any antibody)
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