PLPP_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PDXP , CIN, PLP, PLPP
Protein names and data: PLPP_HUMAN , Pyridoxal phosphate phosphatase; PLP phosphatase; 3.1.3.3; 3.1.3.74 , Chronophin Lenght: 296 a.a.
Mass: 31698 Da
fasta formatted sequence
Function: Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP.
Catalytic activity: Pyridoxal 5'-phosphate + H(2)O = pyridoxal + phosphate. O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate.
Cellular location: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody.
Tissue specificity: Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain.

Database cross-references

UniProt: Q96GD0
Ensembl: ENST00000215904
MIM: 609246
neXtProt: NX_Q96GD0
Antibodypedia: Q96GD0 (may not find the protein thus also not any antibody)
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