PLS4_HUMAN

Source: hRBCD ; ID: IPI00016776
PM19886704
PM23856902
BSc_CH
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: PLSCR4 , GIG43
Protein names and data: PLS4_HUMAN , Phospholipid scramblase 4; PL scramblase 4 , Ca(2+)-dependent phospholipid scramblase 4; Cell growth-inhibiting gene 43 protein; TRA1 Lenght: 329 a.a.
Mass: 37005 Da
fasta formatted sequence
Function: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Cellular location: Membrane; Single-pass type II membrane protein (By similarity).
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes.

Genetic variants

Database cross-references

UniProt: Q9NRQ2
Ensembl: ENST00000354952
Ensembl: ENST00000433593
Ensembl: ENST00000446574
Ensembl: ENST00000493382
MIM: 607612
neXtProt: NX_Q9NRQ2
Antibodypedia: Q9NRQ2 (may not find the protein thus also not any antibody)
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