PLTP_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PLTP
Protein names and data: PLTP_HUMAN , Phospholipid transfer protein , Lipid transfer protein II; Flags: Precursor Lenght: 493 a.a.
Mass: 54739 Da
fasta formatted sequence
Function: Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.
Cellular location: Secreted.
Tissue specificity: Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain.

Genetic variants

Database cross-references

UniProt: P55058
Ensembl: ENST00000354050
Ensembl: ENST00000372431
Ensembl: ENST00000420868
Ensembl: ENST00000477313
MIM: 172425
neXtProt: NX_P55058
Antibodypedia: P55058 (may not find the protein thus also not any antibody)
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