PMGE_HUMAN
Source: hRBCD ; ID: IPI00215979PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: BPGM
Protein names and data: PMGE_HUMAN , Bisphosphoglycerate mutase; BPGM; 5.4.2.4 , 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; 3.1.3.13; 5.4.2.11; 2,3-diphosphoglycerate mutase; DPGM; BPG-dependent PGAM Lenght: 259 a.a.
Mass: 30005 Da
fasta formatted sequence
Function: Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities.
Catalytic activity: 3-phospho-D-glyceroyl phosphate = 2,3- bisphospho-D-glycerate. 2-phospho-D-glycerate = 3-phospho-D-glycerate. 2,3-bisphospho-D-glycerate + H(2)O = 3- phospho-D-glycerate + phosphate.
Disease:
Tissue specificity: Expressed in red blood cells. Expressed in non-erythroid cells of the placenta; present in the syncytiotrophoblast layer of the placental villi at the feto- maternal interface (at protein level).
Genetic variants
Database cross-references
UniProt: P07738Ensembl: ENST00000344924
Ensembl: ENST00000393132
Ensembl: ENST00000418040
MIM: 222800
MIM: 613896
neXtProt: NX_P07738
Antibodypedia: P07738 (may not find the protein thus also not any antibody)
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