PNCB_HUMAN

Source: hRBCD ; ID: IPI00465085
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: NAPRT1 , FHIP
Protein names and data: PNCB_HUMAN , Nicotinate phosphoribosyltransferase; NAPRTase; 6.3.4.21 , FHA-HIT-interacting protein; Nicotinate phosphoribosyltransferase domain-containing protein 1 Lenght: 538 a.a.
Mass: 57578 Da
fasta formatted sequence
Function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP (By similarity).
Catalytic activity: Nicotinate + 5-phospho-alpha-D-ribose 1- diphosphate + ATP + H(2)O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.
Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D- ribonucleotide from nicotinate: step 1/1.
Cellular location: Cytoplasm, cytosol.

Genetic variants

Database cross-references

UniProt: Q6XQN6
Ensembl: ENST00000426292
Ensembl: ENST00000449291
MIM: 611552
neXtProt: NX_Q6XQN6
Antibodypedia: Q6XQN6 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.