POSTN_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: POSTN , OSF2
Protein names and data: POSTN_HUMAN , Periostin; PN , Osteoblast-specific factor 2; OSF-2; Flags: Precursor Lenght: 836 a.a.
Mass: 93314 Da
fasta formatted sequence
Function: Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.
Cellular location: Golgi apparatus (By similarity). Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi (By similarity).
Tissue specificity: Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.

Genetic variants

Database cross-references

UniProt: Q15063
Ensembl: ENST00000379742
Ensembl: ENST00000379747
Ensembl: ENST00000541179
MIM: 608777
neXtProt: NX_Q15063
Antibodypedia: Q15063 (may not find the protein thus also not any antibody)
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