PP1B_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PPP1CB
Protein names and data: PP1B_HUMAN , Serine/threonine-protein phosphatase PP1-beta catalytic subunit; PP-1B; PPP1CD; 3.1.3.16; 3.1.3.53 Lenght: 327 a.a.
Mass: 37187 Da
fasta formatted sequence
Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate. [Myosin light-chain] phosphate + H(2)O = [myosin light-chain] + phosphate.
Cellular location: Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.

Database cross-references

UniProt: P62140
Ensembl: ENST00000296122
Ensembl: ENST00000358506
Ensembl: ENST00000395366
MIM: 600590
neXtProt: NX_P62140
Antibodypedia: P62140 (may not find the protein thus also not any antibody)
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