PP2AA_HUMAN
Source: hRBCD ; ID: IPI00008380PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: PPP2CA
Protein names and data: PP2AA_HUMAN , Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; 3.1.3.16 , Replication protein C; RP-C Lenght: 309 a.a.
Mass: 35594 Da
fasta formatted sequence
Function: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate.
Cellular location: Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity).
Genetic variants
Database cross-references
UniProt: P67775Ensembl: ENST00000481195
MIM: 176915
neXtProt: NX_P67775
Antibodypedia: P67775 (may not find the protein thus also not any antibody)
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