PP4C_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PPP4C , PPP4, PPX
Protein names and data: PP4C_HUMAN , Serine/threonine-protein phosphatase 4 catalytic subunit; PP4C; Pp4; 3.1.3.16 , Protein phosphatase X; PP-X Lenght: 307 a.a.
Mass: 35080 Da
fasta formatted sequence
Function: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate.
Cellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Database cross-references

UniProt: P60510
Ensembl: ENST00000279387
Ensembl: ENST00000561610
MIM: 602035
neXtProt: NX_P60510
Antibodypedia: P60510 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.