PPM1A_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PPM1A , PPPM1A
Protein names and data: PPM1A_HUMAN , Protein phosphatase 1A; 3.1.3.16 , Protein phosphatase 2C isoform alpha; PP2C-alpha; Protein phosphatase IA Lenght: 382 a.a.
Mass: 42448 Da
fasta formatted sequence
Function: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate.
Cellular location: Nucleus. Cytoplasm, cytosol. Membrane (By similarity). Note=Weakly associates at the membrane and N- myristoylation mediates the membrane localization (By similarity).

Database cross-references

UniProt: P35813
Ensembl: ENST00000325642
Ensembl: ENST00000325658
Ensembl: ENST00000395076
Ensembl: ENST00000529574
MIM: 606108
neXtProt: NX_P35813
Antibodypedia: P35813 (may not find the protein thus also not any antibody)
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