PPM1B_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PPM1B , PP2CB
Protein names and data: PPM1B_HUMAN , Protein phosphatase 1B; 3.1.3.16 , Protein phosphatase 2C isoform beta; PP2C-beta Lenght: 479 a.a.
Mass: 52643 Da
fasta formatted sequence
Function: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate.
Cellular location: Cytoplasm, cytosol. Membrane (By similarity). Note=Weakly associates at the membrane and N- myristoylation mediates the membrane localization (By similarity).
Tissue specificity: Highly expressed in heart and skeletal muscle.

Database cross-references

UniProt: O75688
Ensembl: ENST00000282412
Ensembl: ENST00000345249
Ensembl: ENST00000378551
Ensembl: ENST00000409432
Ensembl: ENST00000409895
MIM: 603770
neXtProt: NX_O75688
Antibodypedia: O75688 (may not find the protein thus also not any antibody)
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