PPP6_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: PPP6C , PPP6
Protein names and data: PPP6_HUMAN , Serine/threonine-protein phosphatase 6 catalytic subunit; PP6C; 3.1.3.16; Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed Lenght: 305 a.a.
Mass: 35144 Da
fasta formatted sequence
Function: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.
Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate.
Cellular location: Cytoplasm.
Tissue specificity: Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.

Database cross-references

UniProt: O00743
Ensembl: ENST00000373547
Ensembl: ENST00000415905
Ensembl: ENST00000451402
MIM: 612725
neXtProt: NX_O00743
Antibodypedia: O00743 (may not find the protein thus also not any antibody)
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