PRDX1_HUMAN
Source: hRBCD ; ID: IPI00000874PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: PRDX1 , PAGA, PAGB, TDPX2
Protein names and data: PRDX1_HUMAN , Peroxiredoxin-1; 1.11.1.15 , Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2 Lenght: 199 a.a.
Mass: 22110 Da
fasta formatted sequence
Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
Cellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Genetic variants
Database cross-references
UniProt: Q06830Ensembl: ENST00000262746
Ensembl: ENST00000319248
MIM: 176763
neXtProt: NX_Q06830
Antibodypedia: Q06830 (may not find the protein thus also not any antibody)
Local full text data: click here