PRG2_HUMAN

Source: hRBCD ; ID: IPI00010341
PM19886704
PM23856902
BSc_CH
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: PRG2 , MBP
Protein names and data: PRG2_HUMAN , Bone marrow proteoglycan; BMPG , Proteoglycan 2; Eosinophil granule major basic protein; EMBP; MBP; Pregnancy-associated major basic protein; Flags: Precursor Lenght: 222 a.a.
Mass: 25206 Da
fasta formatted sequence
Function: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Cellular location: Bone marrow proteoglycan: Secreted. Note=The proform is secreted. Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
Tissue specificity: High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.

Genetic variants

Database cross-references

UniProt: P13727
Ensembl: ENST00000311862
Ensembl: ENST00000525955
MIM: 605601
neXtProt: NX_P13727
Antibodypedia: P13727 (may not find the protein thus also not any antibody)
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