PRGC2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PPARGC1B , PERC, PGC1, PGC1B, PPARGC1
Protein names and data: PRGC2_HUMAN , Peroxisome proliferator-activated receptor gamma coactivator 1-beta; PGC-1-beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta , PGC-1-related estrogen receptor alpha coactivator Lenght: 1023 a.a.
Mass: 113222 Da
fasta formatted sequence
Function: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure.
Cellular location: Nucleus.
Tissue specificity: Ubiquitous with higher expression in heart, brain and skeletal muscle.

Genetic variants

Variation of PPARGC1B may contribute to the pathogenesis of obesity, with a widespread Ala-203 allele being a risk factor for the development of this common disorders.

Database cross-references

UniProt: Q86YN6
Ensembl: ENST00000309241
Ensembl: ENST00000360453
Ensembl: ENST00000394320
Ensembl: ENST00000403750
MIM: 608886
neXtProt: NX_Q86YN6
Antibodypedia: Q86YN6 (may not find the protein thus also not any antibody)
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