PRUNE_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PRUNE
Protein names and data: PRUNE_HUMAN , Protein prune homolog; hPrune; 3.6.1.1 , Drosophila-related expressed sequence 17; DRES-17; DRES17; HTcD37 Lenght: 453 a.a.
Mass: 50200 Da
fasta formatted sequence
Function: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.
Catalytic activity: Diphosphate + H(2)O = 2 phosphate.
Cellular location: Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
Tissue specificity: Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.

Genetic variants

Database cross-references

UniProt: Q86TP1
Ensembl: ENST00000271620
Ensembl: ENST00000368934
Ensembl: ENST00000368935
Ensembl: ENST00000368936
Ensembl: ENST00000368937
neXtProt: NX_Q86TP1
Antibodypedia: Q86TP1 (may not find the protein thus also not any antibody)
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