PSA3_HUMAN

Source: hRBCD ; ID: IPI00171199
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: PSMA3 , HC8, PSC8
Protein names and data: PSA3_HUMAN , Proteasome subunit alpha type-3; 3.4.25.1 , Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8 Lenght: 255 a.a.
Mass: 28433 Da
fasta formatted sequence
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
Catalytic activity: Cleavage of peptide bonds with very broad specificity.
Cellular location: Cytoplasm. Nucleus.

Database cross-references

UniProt: P25788
Ensembl: ENST00000216455
Ensembl: ENST00000412908
MIM: 176843
MIM: 176845
neXtProt: NX_P25788
Antibodypedia: P25788 (may not find the protein thus also not any antibody)
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