PSA7_HUMAN

Source: hRBCD ; ID: IPI00024175
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: PSMA7 , HSPC
Protein names and data: PSA7_HUMAN , Proteasome subunit alpha type-7; 3.4.25.1 , Proteasome subunit RC6-1; Proteasome subunit XAPC7 Lenght: 248 a.a.
Mass: 27887 Da
fasta formatted sequence
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
Catalytic activity: Cleavage of peptide bonds with very broad specificity.
Cellular location: Cytoplasm. Nucleus.

Database cross-references

UniProt: O14818
Ensembl: ENST00000370858
Ensembl: ENST00000370861
Ensembl: ENST00000370873
MIM: 606607
neXtProt: NX_O14818
Antibodypedia: O14818 (may not find the protein thus also not any antibody)
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