PSA_HUMAN

Source: hRBCD ; ID: IPI00026216
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: NPEPPS , PSA
Protein names and data: PSA_HUMAN , Puromycin-sensitive aminopeptidase; PSA; 3.4.11.14 , Cytosol alanyl aminopeptidase; AAP-S Lenght: 919 a.a.
Mass: 103276 Da
fasta formatted sequence
Function: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.
Catalytic activity: Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.
Cellular location: Cytoplasm, cytosol. Nucleus (Potential).
Tissue specificity: Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level).

Database cross-references

UniProt: P55786
Ensembl: ENST00000322157
MIM: 606793
neXtProt: NX_P55786
Antibodypedia: P55786 (may not find the protein thus also not any antibody)
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