PSB5_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: PSMB5 , LMPX, MB1, X
Protein names and data: PSB5_HUMAN , Proteasome subunit beta type-5; 3.4.25.1 , Macropain epsilon chain; Multicatalytic endopeptidase complex epsilon chain; Proteasome chain 6; Proteasome epsilon chain; Proteasome subunit MB1; Proteasome subunit X; Flags: Precursor Lenght: 263 a.a.
Mass: 28480 Da
fasta formatted sequence
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity).
Catalytic activity: Cleavage of peptide bonds with very broad specificity.
Cellular location: Cytoplasm. Nucleus.

Genetic variants

Database cross-references

UniProt: P28074
Ensembl: ENST00000361611
Ensembl: ENST00000425762
Ensembl: ENST00000493471
MIM: 600306
neXtProt: NX_P28074
Antibodypedia: P28074 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.