PSDE_HUMAN

Source: hRBCD ; ID: IPI00024821
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: PSMD14 , POH1
Protein names and data: PSDE_HUMAN , 26S proteasome non-ATPase regulatory subunit 14; 3.4.19.- , 26S proteasome regulatory subunit RPN11; 26S proteasome-associated PAD1 homolog 1 Lenght: 310 a.a.
Mass: 34577 Da
fasta formatted sequence
Function: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
Tissue specificity: Widely expressed. Highest levels in heart and skeletal muscle.

Database cross-references

UniProt: O00487
Ensembl: ENST00000409682
MIM: 607173
neXtProt: NX_O00487
Antibodypedia: O00487 (may not find the protein thus also not any antibody)
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