PSMG2_HUMAN

Source: PM19886704
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PSMG2 , HCCA3, PAC2, TNFSF5IP1
Protein names and data: PSMG2_HUMAN , Proteasome assembly chaperone 2; PAC-2 , Hepatocellular carcinoma-susceptibility protein 3; Tumor necrosis factor superfamily member 5-induced protein 1 Lenght: 264 a.a.
Mass: 29396 Da
fasta formatted sequence
Function: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Cellular location: Nucleus (By similarity).
Tissue specificity: Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue.

Database cross-references

UniProt: Q969U7
Ensembl: ENST00000317615
MIM: 609702
neXtProt: NX_Q969U7
Antibodypedia: Q969U7 (may not find the protein thus also not any antibody)
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