PTN11_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: PTPN11 , PTP2C, SHPTP2
Protein names and data: PTN11_HUMAN , Tyrosine-protein phosphatase non-receptor type 11; 3.1.3.48 , Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3 Lenght: 597 a.a.
Mass: 68436 Da
fasta formatted sequence

Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Disease:
Cellular location: Cytoplasm.
Tissue specificity: Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Genetic variants

Database cross-references

UniProt: Q06124
Ensembl: ENST00000351677
Ensembl: ENST00000392597
MIM: 151100
MIM: 156250
MIM: 163950
MIM: 176876
MIM: 607785
neXtProt: NX_Q06124
Antibodypedia: Q06124 (may not find the protein thus also not any antibody)
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