PTN6_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PTPN6 , HCP, PTP1C
Protein names and data: PTN6_HUMAN , Tyrosine-protein phosphatase non-receptor type 6; 3.1.3.48 , Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1 Lenght: 595 a.a.
Mass: 67561 Da
fasta formatted sequence
Function: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Cellular location: Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1.
Tissue specificity: Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

Database cross-references

UniProt: P29350
Ensembl: ENST00000318974
Ensembl: ENST00000399448
Ensembl: ENST00000447931
Ensembl: ENST00000456013
Ensembl: ENST00000594686
Ensembl: ENST00000595623
Ensembl: ENST00000595832
Ensembl: ENST00000599028
MIM: 176883
neXtProt: NX_P29350
Antibodypedia: P29350 (may not find the protein thus also not any antibody)
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