PTPA_HUMAN

Source: hRBCD ; ID: IPI00477616
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: PPP2R4 , PTPA
Protein names and data: PTPA_HUMAN , Serine/threonine-protein phosphatase 2A activator; 5.2.1.8 , PP2A, subunit B', PR53 isoform; Phosphotyrosyl phosphatase activator; PTPA; Serine/threonine-protein phosphatase 2A regulatory subunit 4; Serine/threonine-protein phosphatase 2A regulatory subunit B' Lenght: 358 a.a.
Mass: 40668 Da
fasta formatted sequence
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: Widely expressed.

Genetic variants

Database cross-references

UniProt: Q15257
Ensembl: ENST00000337738
Ensembl: ENST00000355007
Ensembl: ENST00000357197
Ensembl: ENST00000358994
Ensembl: ENST00000393370
MIM: 600756
neXtProt: NX_Q15257
Antibodypedia: Q15257 (may not find the protein thus also not any antibody)
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