Source: BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: PTPRC , CD45
Protein names and data: PTPRC_HUMAN , Receptor-type tyrosine-protein phosphatase C; , Leukocyte common antigen; L-CA; T200; CD45; Flags: Precursor Lenght: 1304 a.a.
Mass: 147254 Da
fasta formatted sequence

Function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Cellular location: Membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.

Genetic variants

Database cross-references

UniProt: P08575
Ensembl: ENST00000367376
Ensembl: ENST00000573477
Ensembl: ENST00000573679
Ensembl: ENST00000594404
MIM: 126200
MIM: 151460
MIM: 608971
neXtProt: NX_P08575
Antibodypedia: P08575 (may not find the protein thus also not any antibody)
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