PUR6_HUMAN

Source: hRBCD ; ID: IPI00217223
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: PAICS , ADE2, AIRC, PAIS
Protein names and data: PUR6_HUMAN , Multifunctional protein ADE2; Phosphoribosylaminoimidazole-succinocarboxamide synthase; 6.3.2.6 , SAICAR synthetase; Phosphoribosylaminoimidazole carboxylase; 4.1.1.21; AIR carboxylase; AIRC Lenght: 425 a.a.
Mass: 47079 Da
fasta formatted sequence
Catalytic activity: ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate. 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).
Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5- amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.

Genetic variants

Database cross-references

UniProt: P22234
Ensembl: ENST00000264221
Ensembl: ENST00000399688
Ensembl: ENST00000512576
MIM: 172439
neXtProt: NX_P22234
Antibodypedia: P22234 (may not find the protein thus also not any antibody)
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