PUR9_HUMAN

Source: hRBCD ; ID: IPI00289499
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: ATIC , PURH , OK/SW-cl.86
Protein names and data: PUR9_HUMAN , Bifunctional purine biosynthesis protein PURH; Phosphoribosylaminoimidazolecarboxamide formyltransferase; 2.1.2.3 , 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase; IMP cyclohydrolase; 3.5.4.10; ATIC; IMP synthase; Inosinicase Lenght: 592 a.a.
Mass: 64616 Da
fasta formatted sequence
Function: Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.
Catalytic activity: 10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. IMP + H(2)O = 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide: step 1/1.
Disease:

Genetic variants

Database cross-references

UniProt: P31939
Ensembl: ENST00000236959
Ensembl: ENST00000435675
MIM: 601731
MIM: 608688
neXtProt: NX_P31939
Antibodypedia: P31939 (may not find the protein thus also not any antibody)
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