PURB_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PURB
Protein names and data: PURB_HUMAN , Transcriptional activator protein Pur-beta , Purine-rich element-binding protein B Lenght: 312 a.a.
Mass: 33241 Da
fasta formatted sequence
Function: Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity).
Cellular location: Nucleus.
Tissue specificity: Expressed in myocardium of heart failure patients.

Database cross-references

UniProt: Q96QR8
Ensembl: ENST00000395699
MIM: 608887
neXtProt: NX_Q96QR8
Antibodypedia: Q96QR8 (may not find the protein thus also not any antibody)
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