Source: BD_CD
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: PVRL3 , PRR3
Protein names and data: PVRL3_HUMAN , Poliovirus receptor-related protein 3 , CDw113; Nectin-3; CD113; Flags: Precursor Lenght: 549 a.a.
Mass: 61002 Da
fasta formatted sequence

Function: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
Cellular location: Cell membrane; Single-pass membrane protein (Potential).
Tissue specificity: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

Genetic variants

Database cross-references

UniProt: Q9NQS3
Ensembl: ENST00000319792
Ensembl: ENST00000485303
Ensembl: ENST00000493615
MIM: 607147
neXtProt: NX_Q9NQS3
Antibodypedia: Q9NQS3 (may not find the protein thus also not any antibody)
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