PYR1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CAD
Protein names and data: PYR1_HUMAN , CAD protein; Glutamine-dependent carbamoyl-phosphate synthase; 6.3.5.5; Aspartate carbamoyltransferase; 2.1.3.2; Dihydroorotase; 3.5.2.3 Lenght: 2225 a.a.
Mass: 242984 Da
fasta formatted sequence
Function: This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
Catalytic activity: 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. (S)-dihydroorotate + H(2)O = N-carbamoyl-L- aspartate.
Pathway: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.
Cellular location: Cytoplasm. Nucleus. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.

Genetic variants

Database cross-references

UniProt: P27708
Ensembl: ENST00000264705
MIM: 114010
neXtProt: NX_P27708
Antibodypedia: P27708 (may not find the protein thus also not any antibody)
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