PZP_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PZP , CPAMD6
Protein names and data: PZP_HUMAN , Pregnancy zone protein , C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6; Flags: Precursor Lenght: 1482 a.a.
Mass: 163863 Da
fasta formatted sequence
Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Cellular location: Secreted.
Tissue specificity: Plasma. Prominent constituent of late- pregnancy sera.

Genetic variants

Database cross-references

UniProt: P20742
Ensembl: ENST00000261336
Ensembl: ENST00000381997
MIM: 176420
neXtProt: NX_P20742
Antibodypedia: P20742 (may not find the protein thus also not any antibody)
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