QOR_HUMAN

Source: PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: CRYZ
Protein names and data: QOR_HUMAN , Quinone oxidoreductase; 1.6.5.5 , NADPH:quinone reductase; Zeta-crystallin Lenght: 329 a.a.
Mass: 35207 Da
fasta formatted sequence
Function: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.
Catalytic activity: NADPH + 2 quinone = NADP(+) + 2 semiquinone.
Cellular location: Cytoplasm.
Tissue specificity: Only very low amounts in the lens.

Genetic variants

Database cross-references

UniProt: Q08257
Ensembl: ENST00000340866
Ensembl: ENST00000370871
Ensembl: ENST00000370872
Ensembl: ENST00000417775
MIM: 123691
neXtProt: NX_Q08257
Antibodypedia: Q08257 (may not find the protein thus also not any antibody)
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