RAB21_HUMAN

Source: hRBCD ; ID: IPI00007755
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: RAB21 , KIAA0118
Protein names and data: RAB21_HUMAN , Ras-related protein Rab-21; Flags: Precursor Lenght: 225 a.a.
Mass: 24348 Da
fasta formatted sequence
Function: Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis.
Cellular location: Endoplasmic reticulum membrane; Lipid-anchor (By similarity). Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Note=In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm. During mitosis, in mid-telophase, localized in the ingressing cleavage furrow. In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells.
Tissue specificity: Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression.

Database cross-references

UniProt: Q9UL25
Ensembl: ENST00000261263
MIM: 612398
neXtProt: NX_Q9UL25
Antibodypedia: Q9UL25 (may not find the protein thus also not any antibody)
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