RAGP1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RANGAP1 , KIAA1835, SD
Protein names and data: RAGP1_HUMAN , Ran GTPase-activating protein 1; RanGAP1 Lenght: 587 a.a.
Mass: 63542 Da
fasta formatted sequence
Function: GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
Cellular location: Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore (By similarity). Cytoplasm, cytoskeleton, spindle pole (By similarity). Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation.
Tissue specificity: Highly expressed in brain, thymus and testis.

Genetic variants

Database cross-references

UniProt: P46060
Ensembl: ENST00000356244
Ensembl: ENST00000405486
Ensembl: ENST00000455915
MIM: 602362
neXtProt: NX_P46060
Antibodypedia: P46060 (may not find the protein thus also not any antibody)
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