RANB3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RANBP3
Protein names and data: RANB3_HUMAN , Ran-binding protein 3; RanBP3 Lenght: 567 a.a.
Mass: 60210 Da
fasta formatted sequence
Function: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF- beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: Widely expressed with high levels in testis and heart.

Genetic variants

Database cross-references

UniProt: Q9H6Z4
Ensembl: ENST00000034275
Ensembl: ENST00000340578
Ensembl: ENST00000439268
MIM: 603327
neXtProt: NX_Q9H6Z4
Antibodypedia: Q9H6Z4 (may not find the protein thus also not any antibody)
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